Accession Number : ADP004411

Title :   Bacterial Resistance to Topical Agents,

Corporate Author : ARMY INST OF SURGICAL RESEARCH FORT SAM HOUSTON TX

Personal Author(s) : McManus,A. T.

Report Date : 21 JAN 1983

Pagination or Media Count : 5

Abstract : Sulfonamide resistance was greater than 78% in gram-negative organisms isolated during the last 12 months. This is a continuation of our previous experience. Sulfadiazine (SD) in silver-sulfadiazine (AgSD) is the only bacteriologically active sulfonamide used on our burn ward. We investigated the requirement of sulfadiazine for the in vitro activity of silver-sulfadiazine. A bacteriologically inactive analog of sulfadiazine was synthesized. The structure of sodium salts of sulfadiazine and the synthesized analog benzenesulfonamidopyrimidine (ISR-44) are presented in Figure 1. As can be seen, the two structures are very similar except that the analog does not have the N-4 amino group (para-amino) necessary for paraminobenzoic acid antagonism. The silver salts of sulfadiazine and its analog were prepared. The two sodium salts and the two silver salts were then examined for in vitro and in vivo (burned rat) activity.

Descriptors :   *SULFADIAZINE, *SULFONAMIDES, *BURNS(INJURIES), BACTERIA, RESISTANCE(BIOLOGY), RATS, TABLES(DATA), SYMPOSIA

Distribution Statement : APPROVED FOR PUBLIC RELEASE