Accession Number : ADP004987

Title :   HPLC (High Performance Liquid Chromotography) Optimization on a Low-Cost Microcomputer,

Corporate Author : AIR FORCE ROCKET PROPULSION LAB EDWARDS AFB CA

Personal Author(s) : Coolidge,M. B. ; Wurzbach,R. A. ; Lindsay,L. L. ; Carver,J. G.

Report Date : JAN 1985

Pagination or Media Count : 5

Abstract : We developed a High Performance Liquid Chromotography (HPLC) Optimization program to solve a three solvent, 2 to 15 peak system using a 32K microcomputer. Although other programs accomplish similar types of data reduction, we were interested in a computer code that was user friendly and did not require an expensive mainframe computer. The computer code can output to: an internal graphics display, an external plotter, or an external printer. One can choose to solve the following: graphs showing desired iso-resolution lines of two peaks, graphs showing overall resolution of all peaks, best solution composition to maximize overall peak resolution, or complete peak analysis at a given solution composition. We run the program on an HP-85 system. Because the program is written in less than 32K of BASIC, it should be easily adapted to other microcomputers (Apple, Commodore, etc.). We have verified the code experimentally. The code and matching experimental data will be discussed. (Author)

Descriptors :   *LIQUID CHROMATOGRAPHY, *COMPUTER APPLICATIONS, *COMPUTER PROGRAMS, SOLVENTS, CHEMICAL COMPOSITION, SEPARATION, MIXTURES, PREDICTIONS, MICROCOMPUTERS, NITROSAMINES, AROMATIC COMPOUNDS, STABILIZATION, SOLID PROPELLANTS, SYMPOSIA

Distribution Statement : APPROVED FOR PUBLIC RELEASE