Accession Number : ADP005660

Title :   Pharmacological Approaches to Performance Enhancement in Animals,

Corporate Author : TROPONWERKE GMBH AND CO COLOGNE GERMANY (F R)

Personal Author(s) : Spencer, D. G., Jr. ; Schuurman, T. ; Benz, U. ; Horvath, E. ; Traber, J.

Report Date : MAR 1987

Pagination or Media Count : 11

Abstract : Drug effects were studied on learning and working memory performance in young, normal rats, as well as on reactions to hypoxia and stress. While some of the treatments reduced cognitive parameters under normal conditions, none improved them in a meaningful way. However, several substances were found to improve performance disrupted by exposure to hypoxia. These substances included piracetam, nimodipine, and ipsapirone. An additional characteristics of ipsapirone was an amelioration of negative responses to stress. Due to the well-understood mechanisms of action of nimodipine and ipsapirone, their low toxicity, and their lack of negative effects on normal cognitive performance, it is suggested that these drugs could prove to be useful therapeutic agents under conditions of high information processing load.

Descriptors :   *PERFORMANCE(HUMAN), *HYPOXIA, *DRUGS, THERAPY, STRESS(PHYSIOLOGY), MEMORY(PSYCHOLOGY), LEARNING.

Subject Categories : Psychology
      Stress Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE