Accession Number : ADP006104

Title :   Measurement and Classification of the Mode of Action of Antidepressant Drugs,

Corporate Author : ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT NEUILLY-SUR-SEINE (FRAN CE)

Personal Author(s) : Frauendorf, Albrecht ; Johnson, David ; Demisch, Lothar

Report Date : FEB 1988

Pagination or Media Count : 9

Abstract : In a comparison of the chronic effects on the central nervous system of five new generation antidepressants, we performed a dose-response study with 5 - 7 healthy subjects per substance. Following standard medical screening, we made intraindividual comparisons after one week at each of the three dosages. We compared two MAO-inhibitors, a NA-reuptake inhibitor, a Serotonine-reuptake inhibitor and an a1/a2 adrenergic receptor and Serotonin s2 - receptor - antagonist. The visual evoked potentials were recorded from electrode position ''Oz'' between O1 and O2. The brightness, contrast and colour channels of the visual system were stimulated using on-off, checkerboard and colour changes respectively. After digitizing, the evoked potentials were subjected to Fourier filtering and analysed in the standard EEG frequency ranges delta, theta, alpha and beta. This improved stability and precision of measurement without phase shifts. The beta and theta components indicated the best response. (js)

Descriptors :   *CENTRAL NERVOUS SYSTEM, CHANNELS, COLORS, DOSAGE, ELECTRODES, FILTERS, FOURIER ANALYSIS, MEASUREMENT, MEDICINE, PHASE SHIFT, POSITION(LOCATION), PRECISION, RESPONSE(BIOLOGY), VISION.

Subject Categories : Psychology
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE