Accession Number : ADP006105

Title :   Measurement of Electrical Activity in the CNS with Cortical Evoked Potentials and EEG: Efficacy Profiles of Drugs Using Factor Analysis,

Corporate Author : ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT NEUILLY-SUR-SEINE (FRAN CE)

Personal Author(s) : Johnson, David ; Frauendorf, Albrecht ; Offenloch, Kurt

Report Date : FEB 1988

Pagination or Media Count : 8

Abstract : In a series of experiments with 20 healthy, subjects per substance, the influences of a new nootropic drug and three cardiovascular agents on the CNS were measured and placebo controlled. The EEG and visual cortical evoked potentials were recorded from electrode position ''Oz'' between O1 and O2 according to the 10-20 system. Three channels of the visual system were selectively stimulated (contrast, brightness and colour using checkerboard, flash and colour change). Acute and chronic studies are reported. Each VEP was filtered into the standard EEG-frequency ranges. Latency changes of the EP were evaluated in each range and analysed with the Fourier technique. Both cardiovascular substances (an anti-hypertonic and a bradycardiac agent) caused a significant latency increase of beta-components with apparent latencies of 80-100 ms. This attenuation was shown in the contrast and even stronger in the colour channel of the visual system. The results indicate a two-component effect, i.e on the central nervous and the cardiovascular systems. (js)

Descriptors :   *ELECTROENCEPHALOGRAPHY, ATTENUATION, CARDIOVASCULAR AGENTS, CARDIOVASCULAR SYSTEM, CHANNELS, COLORS, DRUGS, ELECTRICAL PROPERTIES, ELECTRODES, FACTOR ANALYSIS, FOURIER ANALYSIS, MEASUREMENT, PLACEBOS, POSITION(LOCATION), PROFILES, VISION.

Subject Categories : Psychology

Distribution Statement : APPROVED FOR PUBLIC RELEASE