Accession Number : ADP006106

Title :   An approach in determining the effects of psychostimulants on cerebral electrical activity in the non-human primate(Une Approche Des Effets De Psychostimulants Sur L'Activite Electrique Cerebrale Chez Le Primate Non Humain),

Corporate Author : ADVISORY GROUP FOR AEROSPACE RESEARCH AND DEVELOPMENT NEUILLY-SUR-SEINE (FRAN CE)

Personal Author(s) : Lagarde, D. ; Milhaud, C.

Report Date : FEB 1988

Pagination or Media Count : 11

Abstract : The purpose of this work was to determine the very original properties of this new psychostimulant agent against two other conventional stimulants; viz., caffeine and d-amphetamine. (The drug d-amphetamine is still given to aircrew in France; and, of course, it has well-known side effects.) The new drug was studied in our laboratory in the non-human primate, the rhesus monkey. At the dosage indicated -- 25 mg/kg -- there were no side effects in the performance of the animal nor in its vegetative parameters; viz., in blood pressure and heart rate. The main effect of the drug was that it kept the animal awake, though not as a stimulant. This effect would give the impression that the drug is not comprised of an amphetamine-like type of molecule. It's an action which is quite specific - as based on other studies in apes and rats -- in that is appears to work on post-synaptic brain centres at that level of dosage. Of course, at a higher dosage it would probably have a doping effect. (js)

Descriptors :   *HEART RATE, ANIMALS, APES, BLOOD PRESSURE, CAFFEINE, DOPING, DOSAGE, DRUGS, FRANCE, PARAMETERS, RATS, RHESUS MONKEYS, STIMULI, VEGETATION.

Subject Categories : Psychology

Distribution Statement : APPROVED FOR PUBLIC RELEASE