Accession Number : ADP006356

Title :   Improving Toxicology Testing Protocols Using Computer Simulations,

Corporate Author : HARRY G ARMSTRONG AEROSPACE MEDICAL RESEARCH LAB WRIGHT-PATTERSON AFB OH

Personal Author(s) : Clewell, Harvey J., III ; Andersen, Melvin E.

Report Date : JUL 1990

Pagination or Media Count : 21

Abstract : Computer simulation can be used to integrate existing toxicity information within a biologically realistic framework. Simulation models calculate relevant measures of target tissue dose based on physiological, biochemical, and physicochemical properties and readily support the dose, route, species, and interchemical extrapolations necessary for human risk assessment. Because these models require very specific information, much of which can be obtained in vitro, they are much less dependent on extensive animal experiments than conventional risk assessment methods. With continuing development, simulation modeling will become an invaluable tool for improving experimental designs, for interpreting animal toxicity tests, and for estimating the importance of the animal toxicity observations for people.

Descriptors :   *TOXICITY, *COMPUTERIZED SIMULATION, *DOSAGE, *PREDICTIONS, ANIMALS, HUMANS, MODELS, PHYSICOCHEMICAL PROPERTIES, RISK, BIOCHEMISTRY, SYMPOSIA.

Subject Categories : Toxicology
      Computer Programming and Software

Distribution Statement : APPROVED FOR PUBLIC RELEASE