Accession Number : ADP006359

Title :   Toxicology of Chemical Mixtures: Experimental Approaches, Underlying Concepts, and Some Results,

Corporate Author : NATIONAL INST OF ENVIRONMENTAL HEALTH SCIENCES RESEARCH TRIANGLE PARK NC

Personal Author(s) : Yang, Raymond S. ; Long, H. L. ; Boorman, Gary A.

Report Date : JUL 1990

Pagination or Media Count : 16

Abstract : The toxicology of chemical mixtures will be the toxicology of the 1990s and beyond. While this branch of toxicology most closely reflects the actual human exposure situation, as yet, there is no standard protocol or consensus methodology for investigating the toxicology of mixtures. Thus, in this emerging science, experimentation is required just to develop a broadly applicable evaluation system. Several examples are discussed to illustrate the different experimental designs and the concepts behind each. These include the health effects studies of Love Canal soil samples, the Lake Ontario Coho salmon, the water samples repurified from secondary sewage in the city of Denver Potable Water Reuse Demonstration Plant, and the National Toxicology Program (NTP) effort on a mixture of 25 frequently detected groundwater contaminants derived from hazardous waste disposal sites. In the last instance, an extensive research program has been ongoing for the last two years at the NTP, encompassing general toxicology, immunotoxicology, developmental and reproductive toxicology, biochemical toxicology, myelotoxicology, genetic toxicology, neurobehavioral toxicology, and hepato- and renal toxicology.

Descriptors :   *CHEMICALS, *MIXTURES, *TOXICOLOGY, CANALS, CONTAMINANTS, TEST METHODS, SYMPOSIA, GENETICS, HEALTH, HUMANS, LAKE ONTARIO, LAKES, METHODOLOGY, SECONDARY, SEWAGE, SITES, SOILS, STANDARDS, URBAN AREAS, WASTE DISPOSAL, WATER.

Subject Categories : Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE