Accession Number : ADP006361

Title :   Mechanism of the Lethal Interaction of Chlordecone and CCl4 at Nontoxic Doses,

Corporate Author : MISSISSIPPI UNIV MEDICAL CENTER JACKSON DEPT OF PHARMACOLOGY AND TOXICOLOGY

Personal Author(s) : Mehendale, Harihara M.

Report Date : JUL 1990

Pagination or Media Count : 31

Abstract : There is a significant interest in the possibility of unusual toxicity due to interaction of toxic chemicals upon environmental or occupational exposures even though such exposures may involve levels ordinarily considered harmless individually. While many laboratory and experimental models exist for such interactions, progress in this area of toxicology has suffered for want of a model where the two interactants are individually nontoxic. We developed such a model where prior exposure to nontoxic levels of the pesticide Kepone (chlordecone) results in a 67-fold amplification of carbon tetrachloride (CC14) lethality in experimental animals. The mechanism(s) by which chlordecone amplifies the hepatotoxicity of halomethanes such as CC14, chloroform (CHC13), and bromotrichloro (BrCC13) has been a subject of intense study. The biological effects of this interaction include extensive hepatotoxicity characterized by histopathological alterations, hepatic dysfunction, and perturbation of related biochemical parameters. Close structural analogs of chlordecone such as mirex and photomirex do not share the propensity of chlordecone to potentiate halomethane toxicity.

Descriptors :   *LETHALITY, *PESTICIDES, *TOXICITY, *CARBON TETRACHLORIDE, AMPLIFICATION, ANIMALS, CHEMICALS, DYSFUNCTION, INTERACTIONS, LABORATORY ANIMALS, MODELS, TOXICOLOGY, SUBLETHAL DOSAGE, SYMPOSIA, DOSAGE, EXPOSURE(PHYSIOLOGY).

Subject Categories : Toxicology
      Environmental Health and Safety

Distribution Statement : APPROVED FOR PUBLIC RELEASE