Accession Number : ADP006363

Title :   Genetic Determinants of Hepatocarcinogenesis in the B6C3F1 Mouse,

Corporate Author : WISCONSIN UNIV-MADISON MCARDLE LAB FOR CANCER RESEARCH

Personal Author(s) : Drinkwater, Norman R. ; Hanigan, Marie ; Kemp, Christopher J.

Report Date : JUL 1990

Pagination or Media Count : 12

Abstract : The B6C3F1 mouse is highly susceptible to the induction of liver tumors because of the contribution of a specific gene, an allele of the hepatocarcinogen sensitivity (Hcs) locus, inherited from its C3H inbred parent. This gene affects the rate of growth of preneoplastic hepatic lesions and results in the more rapid appearance of hepatic neoplasms in mice carrying the C3H allele in comparison to mice homozygous for the resistant C57BU6 allele. The Hcs locus also acts synergistically with at least one class of chemical tumor promoters, the halogenated aromatic hydrocarbons. Because of this genetic promotion of hepatocarcinogenesis, B6C3F, mice are more sensitive to liver tumor induction by both genotoxic and nongenotoxic carcinogens.

Descriptors :   *CARCINOGENS, *GENETICS, *LIVER, *MICE, *NEOPLASMS, AROMATIC HYDROCARBONS, CHEMICALS, COMPARISON, GENES, LESIONS, LOCUS, SYMPOSIA.

Subject Categories : Genetic Engineering and Molecular Biology
      Toxicology

Distribution Statement : APPROVED FOR PUBLIC RELEASE