Accession Number : ADP006556

Title :   Mechanisms of Immune Failure in Burn Injury,

Corporate Author : DEFENCE AND CIVIL INST OF ENVIRONMENTAL MEDICINE DOWNSVIEW (ONTARIO)

Personal Author(s) : Sparkes, Brian G.

Report Date : APR 1992

Pagination or Media Count : 12

Abstract : The burden on military medical services in handling burn casualties is daunting as all physiological systems will become affected. Severe burns in a battlefield setting have a very low salvage rate, to a great degree because of the immune failure which invariably develops. Evaluations of responses of lymphocytes taken from burn patients over several weeks following the burn (> 30% TBSA), have revealed that the immune failure which follows thermal injury involves T cell activation events. Interleukin 2, which is normally produced by activated T lymphocytes, is very poorly produced by cells cultivated in vitro taken from non-surviving patients, whereas some production continues, although at below normal levels, in patients who ultimately survive their injury.

Descriptors :   *BATTLEFIELDS, *MEDICAL SERVICES, *T LYMPHOCYTES, *WOUNDS AND INJURIES, *BURNS(INJURIES), CASUALTIES, CELLS, FAILURE, HANDLING, LYMPHOCYTES, PATIENTS, PRODUCTION, RESPONSE, SALVAGE.

Subject Categories : Medicine and Medical Research
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Distribution Statement : APPROVED FOR PUBLIC RELEASE