Accession Number : ADP006573

Title :   Absence of Protective Immunity Against Diphtheria in a Large Proportion of Young Adults,

Corporate Author : SCLAVO S P A RESEARCH CENTER SIENA (ITALY)

Personal Author(s) : Rappuoli, R. ; Podda, A. ; Giovannoni, F. ; Nencioni, L. ; Pragallo, M.

Report Date : APR 1992

Pagination or Media Count : 2

Abstract : The schedule of vaccination which is recommended worldwide for diphtheria, tetanus and other diseases, provides good immunity during childhood. However, little attention has been paid to keep an effective immunity in adults. We have collected sera from 334 recruits of the Italian Army and tested them for the presence of protective immunity against diphtheria and tetanus. In vivo neutralization assays were performed on rabbits and mice -and the values below 1/100 IU/mi were considered negative. 22.9% of the recruits were negative for diphtheria, while only 5.3% of them did not have protective immunity against tetanus.

Descriptors :   *IMMUNIZATION, ADULTS, ARMY, ATTENTION, DISEASES, IMMUNITY, MICE, NEUTRALIZATION, RABBITS, RECRUITS, TETANUS, VALUE.

Subject Categories : Medicine and Medical Research
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Distribution Statement : APPROVED FOR PUBLIC RELEASE