Accession Number : ADP006575

Title :   Clinical and Immunological Response to Vaccination with parenteral or Oral Vaccines in Two Groups of 30 Recruits,

Corporate Author : ROME UNIV (ITALY)

Personal Author(s) : Nisini, Roberto ; Biselli, Roberto ; Matricardi, Paolo M. ; Fattorossi, Andrea ; D'Amelio, Raffaele

Report Date : APR 1992

Pagination or Media Count : 4

Abstract : Typhoid fever is a distinctive acute systemic febrile infection of the mononuclear phagocytes caused by several Salmonella species, mainly S. typhi, S. paratyphi A and B and occasionally S. typhimurium. Men can be infected by contaminated water or food contaminated by a human carrier. With improvements of environmental sanitation in developed countries the incidence of typhoid has gradually dropped. In Italy the incidence of typhoid fever is rapidly declining, but areas with endemic typhoid still persist. Prevention of typhoid fever relays primarily on prevention of exposure, but immunization is indicated in endemic areas, in travellers to these areas, in household contacts of typhoid carriers, in laboratory or sewer workers and in military personnel (1). The use of parenteral vaccines (TAB) has shown to be effective (2-4), but associated with a high incidence of local and systemic adverse reactions 5 .

Descriptors :   *IMMUNIZATION, *PHAGOCYTES, *SALMONELLA, *TYPHOID, *AEROSPACE MEDICINE, FEVERS, FOOD, HUMANS, ITALY, LABORATORIES, PREVENTION, RELAYS, SANITATION, SEWERS, WATER.

Subject Categories : Medicine and Medical Research
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Distribution Statement : APPROVED FOR PUBLIC RELEASE