Accession Number : ADP006576

Title :   Studies of Safety, Infectivity and Immunogenicity of a New Temperature Sensitive (ts) 51-1 Strain of S. Typhi as a New Live Oral Typhoid Fever Vaccine Candidate,

Corporate Author : GEORGETOWN UNIV WASHINGTON DC SCHOOL OF MEDICINE

Personal Author(s) : Bellanti, J. A. ; Zeligs, B. J. ; Vetro, S. ; Pung, Y.H. ; Luccioli, S.

Report Date : APR 1992

Pagination or Media Count : 6

Abstract : This report describes the results of a phase 1 study evaluating the safety, infectivity, and immunogenicity of a new live oral S. typhi ts 51-1 typhoid fever vaccine in the human. Three normal male subjects ranging in age from 20-40 years received 3 oral doses of S. typhi ts 51-1, each dose containing 109 organisms. Prior to and following immunization each subject was carefully monitored by clinical and laboratory parameters over a two week period during which serial specimens of blood and stool were analyzed for the presence of the organism. Blood specimens were also obtained for the determination of serum antibody and cell-mediated immune responses and stool filtrates were analyzed for the development of coproantibody.

Descriptors :   *IMMUNIZATION, ANTIBODIES, BLOOD, CELLS, DETERMINATION, FEVERS, HUMANS, LABORATORIES, MALES, PARAMETERS, PHASE, PHASE STUDIES, RESPONSE, SAFETY, TYPHOID, VACCINES.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE