Accession Number : ADP007173

Title :   An Overview of the affected-Pedigree-Member Method of Linkage Analysis,

Corporate Author : PITTSBURGH UNIV PA

Personal Author(s) : Weeks, Daniel E. ; Lange, Kenneth

Report Date : 1992

Pagination or Media Count : 6

Abstract : Human geneticists have been extremely successful in the past decade in mapping rare disease genes. For common diseases with a substantial genetic component, the payoff for human health is larger, but the mapping problems are harder. There is a need for robust statistical techniques that require minimal assumptions about the mode of inheritance of the disease studied. The affected-pedigree-member (APM) of linkage analysis makes virtually no assumptions about disease transmission except that it is independent of marker transmission in a pedigree. We discuss here an extension of the APM method from single markers to multiple closely linked markers. This extension should improve the power of the APM method to detect linkage.


Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE