Accession Number : ADP007173

Title :   An Overview of the affected-Pedigree-Member Method of Linkage Analysis,

Corporate Author : PITTSBURGH UNIV PA

Personal Author(s) : Weeks, Daniel E. ; Lange, Kenneth

Report Date : 1992

Pagination or Media Count : 6

Abstract : Human geneticists have been extremely successful in the past decade in mapping rare disease genes. For common diseases with a substantial genetic component, the payoff for human health is larger, but the mapping problems are harder. There is a need for robust statistical techniques that require minimal assumptions about the mode of inheritance of the disease studied. The affected-pedigree-member (APM) of linkage analysis makes virtually no assumptions about disease transmission except that it is independent of marker transmission in a pedigree. We discuss here an extension of the APM method from single markers to multiple closely linked markers. This extension should improve the power of the APM method to detect linkage.

Descriptors :   *DISEASES, *HEALTH, GENES, GENETICS, HUMANS, LINKAGES, MAPPING, MARKERS, POWER.

Subject Categories : Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE