Accession Number : ADP008342

Title :   Molecular Determinants in the Delta Selectivity of Deltorphins,

Corporate Author : NATIONAL INST OF ENVIRONMENTAL HEALTH SCIENCES RESEARCH TRIANGLE PARK NC

Personal Author(s) : Lazarus, L. H. ; Salvadori, S. ; Tomatis, R. ; Wilson, W. E.

Report Date : 1992

Pagination or Media Count : 2

Abstract : The deltorphins were discovered in frog skin by their cDNA sequences and the isolated natural peptides contained D-amino acid enantiomer at position 2. Recognition of high delta affinities and delta selectivities of these peptides led to the examination of the molecular determinants required for interaction with opioid receptors.

Descriptors :   *DEOXYRIBONUCLEIC ACIDS, PEPTIDES, AMINO ACIDS, ANALOGS, FROGS, RECEPTOR SITES(PHYSIOLOGY).

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE