Accession Number : ADP008343
Title : A Conformational Study of Achatin-I, an Endogenous Neuropeptide Containing a D-Amino Acid Residue,
Corporate Author : OSAKA UNIV (JAPAN)
Personal Author(s) : Iwashita, Takashi ; Kamatani, Yoshimi ; Minakata, Hiroyuki ; Ishida, Toshimasa ; Nomoto, Kyosuke
Report Date : 1992
Pagination or Media Count : 2
Abstract : Achatin-I was isolated from the suboesophageal and cerebral ganglia of the African giant snail(Achatina fulica Ferussac), and evoked a potent neuroexcitatory effect. The amino acid sequence of achatin-I is H-Gly-D-Phe-Ala-Asp-OH, and it is the first example of an endogenous neuropeptide having a D-amino acid residue. From the same ganglia, an L-Phe derivative of achatin-I was also isolated, and termed as achatin-II.
Descriptors : *AMINO ACIDS, PEPTIDES, SNAILS, X RAYS, CRYSTALLOGRAPHY, SYNTHESIS(CHEMISTRY), JAPAN.
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE