Accession Number : ADP008343

Title :   A Conformational Study of Achatin-I, an Endogenous Neuropeptide Containing a D-Amino Acid Residue,

Corporate Author : OSAKA UNIV (JAPAN)

Personal Author(s) : Iwashita, Takashi ; Kamatani, Yoshimi ; Minakata, Hiroyuki ; Ishida, Toshimasa ; Nomoto, Kyosuke

Report Date : 1992

Pagination or Media Count : 2

Abstract : Achatin-I was isolated from the suboesophageal and cerebral ganglia of the African giant snail(Achatina fulica Ferussac), and evoked a potent neuroexcitatory effect. The amino acid sequence of achatin-I is H-Gly-D-Phe-Ala-Asp-OH, and it is the first example of an endogenous neuropeptide having a D-amino acid residue. From the same ganglia, an L-Phe derivative of achatin-I was also isolated, and termed as achatin-II.

Descriptors :   *AMINO ACIDS, PEPTIDES, SNAILS, X RAYS, CRYSTALLOGRAPHY, SYNTHESIS(CHEMISTRY), JAPAN.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE