Accession Number : ADP008349

Title :   Synthesis and Structural Characterization of Substance P Analogs Containing a Fluoroolefin Peptide Bond Mimic,

Corporate Author : CIBA-GEIGY AG BASEL (SWITZERLAND)

Personal Author(s) : Felder, E. ; Allmendinger, T. ; Fritz, H. ; Hungerbuehler, E. ; Keller, M.

Report Date : 1992

Pagination or Media Count : 2

Abstract : We propose fluoroolefin pseudopeptide bonds as superior replacements of peptidic bonds particularly exposed to proteolytic cleavage. In contrast to plain olefin mimics fluoroolefins aim at reproducing both geometric and electronic features of the peptide bond.

Descriptors :   *SYNTHESIS(CHEMISTRY), ANALOGS, PEPTIDES, OLEFIN POLYMERS, SWITZERLAND.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE