Accession Number : ADP008359
Title : Theory for Protein Aggregation,
Corporate Author : CALIFORNIA UNIV SAN FRANCISCO
Personal Author(s) : Fields, Gregg B. ; Alonso, Darwin O. ; Stigter, Dirk ; Dill, Ken A.
Report Date : 1992
Pagination or Media Count : 3
Abstract : Proteins often aggregate to form biologically inactive precipitates. To better understand this problem, we have developed a mean-field lattice statistical mechanics theory for the equilibrium between native, denatured, and aggregated states of proteins and other random copolymers of hydrophobic and hydrophilic monomers in aqueous solution.
Descriptors : *PROTEINS, BIOLOGICAL INACTIVATION, HYDROPHOBIC PROPERTIES, HYDROPHILIA, POLYMERS, LATTICE DYNAMICS, THEORY, DENSITY.
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE