Accession Number : ADP008360

Title :   Conformational Studies of the Amyloid Protein of Alzheimer's Disease,

Corporate Author : MASSACHUSETTS INST OF TECH CAMBRIDGE

Personal Author(s) : Halverson, Kurt J. ; Anderson, Todd ; Spencer, Richard G. ; Auger, Michele ; McDermott, Ann E.

Report Date : 1992

Pagination or Media Count : 3

Abstract : The presence of extracellular amyloid plaque is characteristic of the Alzheimer's disease (AD) brain. The amyloid consists of a 42 amino acid protein known as the beta protein, in reference to the fact that the plaque contains regular cross-beta fibrillar structure as observed by X-ray fiber diffraction.

Descriptors :   *PROTEINS, BRAIN, AMINO ACIDS, X RAYS, CRYSTALLOGRAPHY, NUCLEAR MAGNETIC RESONANCE, PEPTIDES, IN VIVO ANALYSIS.

Subject Categories : Biochemistry
      Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE