Accession Number : ADP008365

Title :   Synthesis and Biological Activity of Cyclopropane TRH Analogs,

Corporate Author : GEORGIA UNIV ATHENS

Personal Author(s) : Srivastava, V. P. ; Mapelli, C. ; Iturrian, W. B. ; Taylor, E. W. ; Stammer, C. H.

Report Date : 1992

Pagination or Media Count : 4

Abstract : Thyrotropin-releasing hormone (TRH, pGlu-His-Pro-Nh2) is not only essential for maintaining thyrotropin (TSH) secretion, but also mediates diverse responses in the peripheral and central nervous systems. Proton and (13) C NMR studies of TRH have shown the His-Pro amide bond to be conformationally heterogeneous.

Descriptors :   *CYCLOPROPANES, *THYROTROPIN, *PITUITARY HORMONES, HORMONES, SYNTHESIS, BIOLOGY, ANALOGS, CENTRAL NERVOUS SYSTEM, ROTATION, CHEMICAL BONDS.

Subject Categories : Organic Chemistry
      Biochemistry
      Biology

Distribution Statement : APPROVED FOR PUBLIC RELEASE