Accession Number : ADP008370

Title :   The Membrane Mediated Conformation of Dynorphin A(1-13) as Studied by Transferred Nuclear Overhauser Effect Spectroscopy,

Corporate Author : MCMASTER UNIV HAMILTON (ONTARIO)

Personal Author(s) : VAN Gorkom, L. C. ; Lancaster, C. R. ; St-Pierre, S. ; Bothner-By, A. A. ; Epand, R. M.

Report Date : 1992

Pagination or Media Count : 2

Abstract : Dynorphin A is a potent opioid peptide with high specificity for the kappa-opioid receptor. The kappa-agonists are of clinical interest because kappa-receptors have been found to mediate analgesia with low addictive potential. The N-terminal fragment Dynorphin has high potency and kappa selectivity comparable to the natural 17 amino-acid peptide. The membrane is believed to play an important role in the receptor-peptide interactions. We report the conformational analysis of Dynorphin A at the surface of small uni-lamellar phosphatidylcholine vesicles.

Descriptors :   *PEPTIDES, *OPIUM ALKALOIDS, *MEMBRANES(BIOLOGY), *RECEPTOR SITES(PHYSIOLOGY), ANALGESICS, SPECTROSCOPY, CANADA.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE