Accession Number : ADP008374
Title : 1H-NMR Studies of the Structure and Calcium Binding Behavior of the First EGF-Like Domain in Blood Coagulation Factor IX,
Corporate Author : HUNTER COLL NEW YORK
Personal Author(s) : Huang, Linda H. ; Cheng, Hong ; Pardi, Arthur ; Tam, James P. ; Sweeney, William V.
Report Date : 1992
Pagination or Media Count : 2
Abstract : It has been shown that there is no epidermal growth factor (EGF)-receptor binding nor mitogenic activity in the synthetic first EGF-like domain of factor IX(45-87). However, the Gla-independent calcium binding site has been located in this peptide fragment. The sequence-specific assignment of the 1H-NMR resonances and the secondary structure of the peptide have been determined by standard 2D-NMR techniques. Also, the location of the calcium binding site has been investigated.
Descriptors : *GROWTH SUBSTANCES, *RECEPTOR SITES(PHYSIOLOGY), *CALCIUM, *BLOOD COAGULATION, EPIDERMIS, PEPTIDES, FRAGMENTS, SEQUENCES, NUCLEAR MAGNETIC RESONANCE.
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE