Accession Number : ADP008422

Title :   Alanine Scan of Endothelin,

Corporate Author : ROCKEFELLER UNIV NEW YORK

Personal Author(s) : DE Castiglione, R. ; Tam, J. P. ; Liu, W. ; Zhang, J. W. ; Galantino, M.

Report Date : 1992

Pagination or Media Count : 2

Abstract : In Order to get an insight into the endothelin's (ET) structural requirements for vasoconstrictor activity, a series of analogs was synthesized by SPPS, using the Boc-benzyl protecting group strategy. The paper describes the L-alanine scan, in which each non-cysteinyl residue was substituted individually with Ala.

Descriptors :   *PHARMACOLOGICAL ANTAGONISTS, *VASOCONSTRICTING, *ALANINES, ISOMERS, CYSTEINE, VENA CAVA, CONTRACTION, RESIDUES, DOSAGE, ITALY.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE