Accession Number : ADP008423

Title :   D-Amino Acid Scan of Endothelin,

Corporate Author : ROCKEFELLER UNIV NEW YORK

Personal Author(s) : Galantino, M. ; de Castiglione, R. ; Tam, J. P. ; Liu, W. ; Zhang, J. W.

Report Date : 1992

Pagination or Media Count : 2

Abstract : Endothelin-1 (ET) belongs to a family of newly discovered peptides with potent vasoconstrictor properties, probably implicated in the pathophysiology of hypertension, renal failure, vasospasm and other disease states. Here we report a systematic approach based on single-point D-amino-acid substitution of the non-cysteinyl residues.

Descriptors :   *PHARMACOLOGICAL ANTAGONISTS, *VASOCONSTRICTING, *AMINO ACIDS, PEPTIDES, CYSTEINE, ISOMERS, PEPTIDES, VENA CAVA, RESIDUES, BLOOD CIRCULATION, ITALY.

Subject Categories : Anatomy and Physiology
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE