Accession Number : ADP008424
Title : Boc-CCK-4 Derivatives Containing Side Chain Ureas and Amides as Potent and Selective CCK-A Receptor Agonists,
Corporate Author : ABBOTT LABS NORTH CHICAGO IL
Personal Author(s) : Shiosaki, K. ; Lin, C. W. ; Asin, K. E. ; Kopecka, H. ; Craig, R. A.
Report Date : 1992
Pagination or Media Count : 2
Abstract : Analysis of singly substituted ureas revealed that greatest CCK-A potency and selectivity were achieved upon substitution of the phenyl ring at the 2 position. The Me- and Cl-substituted analogs possessed greater binding affinity than their respective CF 3-substituted derivative.
Descriptors : *UREA, *RECEPTOR SITES(PHYSIOLOGY), PEPTIDES, GLYCOSIDE HYDROLASES, AROMATIC COMPOUNDS, PANCREAS, AMIDE HYDROLASES.
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE