Accession Number : ADP008425

Title :   Structure-Activity of C-Terminal Modified Analogs of Ac-CCK-7,

Corporate Author : HOFFMANN-LA ROCHE INC NUTLEY NJ

Personal Author(s) : Tilley, J. W. ; Danho, W. ; Shiuey, S. J. ; Kulesha, I. ; Sarabu, R.

Report Date : 1992

Pagination or Media Count : 2

Abstract : As part of our overall program to develop orally active CCK mimetics for use as appetite suppressants, we require detailed knowledge of the role played by each structural element of CCK at its receptors. Previous SAR with CCK analogs indicates that and intact C-terminal carboxamide is required for full agonist activity while the aromatic ring on the C-terminal phenylalanine may be substituted by lower alkyl or cycloalkyl moieties with only modest effects on binding to either the CCK-A or CCK-B receptors.

Descriptors :   *APPETITE, *RECEPTOR SITES(PHYSIOLOGY), *PEPTIDES, INHIBITORS, PHENYLALANINE, ALANINES, AROMATIC COMPOUNDS, AZIDES.

Subject Categories : Anatomy and Physiology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE