Accession Number : ADP008426

Title :   EGF-Receptor Binding Peptides from Transforming Growth Factor Alpha (TGF Alpha): Evidence for a Multi-Domain Interaction,

Corporate Author : FLORIDA UNIV GAINESVILLE DEPT OF CHEMISTRY

Personal Author(s) : Davies, Donna E. ; Richter, Audrey ; Conlan, J. W. ; Higginbotham, Clement ; Ward, Michael E.

Report Date : 1992

Pagination or Media Count : 3

Abstract : TGF alpha is a small protein which can bind to, and activate, epidermal growth factor receptors (EGF-R) on the surface of epithelial, mesenchymal and a range of cancer cells, causing the initiation of DNA synthesis and subsequent division. Despite intensive efforts using site-directed mutagenesis, synthetic peptide fragments, and determination of the secondary and tertiary folding of TGF alpha in solution, the role and importance of many structural features in mediating EGF-R activation remain ill-defined. We have assayed the ability of EGF-R to bind to peptide fragments of TGF alpha.

Descriptors :   *CANCER, *PROTEINS, *PEPTIDES, *GROWTH SUBSTANCES, RECEPTOR SITES(PHYSIOLOGY), HEPTANES, EPIDERMIS, MUTAGENS, AMINO ACIDS, CELLS(BIOLOGY), GREAT BRITAIN.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE