Accession Number : ADP008428

Title :   A Peptide Model for the Heparin Binding Site on Antithrombin III,

Corporate Author : MASSACHUSETTS INST OF TECH CAMBRIDGE

Personal Author(s) : Coffman, Annemarie I. ; Lansbury, Peter T., Jr

Report Date : 1992

Pagination or Media Count : 3

Abstract : The 432 amino acid glycoprotein Antithrombin III (ATIII) regulates several key steps in the blood clotting cascade by inhibiting serine proteases such as thrombin and factor X sub a. The rate by which ATIII inhibits these enzymes is accelerated 1000-fold by binding to a specific polysaccharide sequence within the carbohydrate chains of heparin. Heparin is a heterogeneous polysulfated proteoglycan, the saccharide portion of which is commonly prescribed in the treatment of thrombosis.

Descriptors :   *THROMBIN, *HEPARIN, *ANTICOAGULANTS, ENZYME INHIBITORS, AMINO ACIDS, THROMBOSIS, PEPTIDES, BLOOD PLASMA, SERINE.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE