Accession Number : ADP008429

Title :   Syntheses and Chemotactic Activities of 2,3-Methanophenylalanine3Chemotactic Peptides,

Corporate Author : NATIONAL INSTITUTES OF HEALTH BETHESDA MD

Personal Author(s) : Kodama, Hiroaki ; Miyazaki, Masaya ; Kondo, Michio ; Sakaguchi, Kazuyasu ; Stammer, Charles H.

Report Date : 1992

Pagination or Media Count : 2

Abstract : A family of N-formyl Met peptides is known to have chemotactic activity for neutrophils and macrophages, and neutrophil activating potency. The SAR of these peptides have been well-documented. Recently structures of to of these peptides have been well-documented. Recently structures of two fMLF (HCO-Met-Leu-Phe-OH, also known as fMLP) receptor proteins were determined. However, analogs which can discriminate among fMLF receptor subtypes has not yet been obtained.

Descriptors :   *PEPTIDES, *CHEMOTAXIS, LEUKOCYTES, POLYMORPHONUCLEAR NEUTROPHILS, ALANINES, AMINO ACIDS, CYCLOPROPANES, PROTEINS, LIGANDS, JAPAN.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE