Accession Number : ADP008429
Title : Syntheses and Chemotactic Activities of 2,3-Methanophenylalanine3Chemotactic Peptides,
Corporate Author : NATIONAL INSTITUTES OF HEALTH BETHESDA MD
Personal Author(s) : Kodama, Hiroaki ; Miyazaki, Masaya ; Kondo, Michio ; Sakaguchi, Kazuyasu ; Stammer, Charles H.
Report Date : 1992
Pagination or Media Count : 2
Abstract : A family of N-formyl Met peptides is known to have chemotactic activity for neutrophils and macrophages, and neutrophil activating potency. The SAR of these peptides have been well-documented. Recently structures of to of these peptides have been well-documented. Recently structures of two fMLF (HCO-Met-Leu-Phe-OH, also known as fMLP) receptor proteins were determined. However, analogs which can discriminate among fMLF receptor subtypes has not yet been obtained.
Descriptors : *PEPTIDES, *CHEMOTAXIS, LEUKOCYTES, POLYMORPHONUCLEAR NEUTROPHILS, ALANINES, AMINO ACIDS, CYCLOPROPANES, PROTEINS, LIGANDS, JAPAN.
Subject Categories : Biochemistry
Distribution Statement : APPROVED FOR PUBLIC RELEASE