Accession Number : ADP008430

Title :   Studies of Dimeric fMLF with High Chemotactic Activities,

Corporate Author : SAGA UNIV (JAPAN)

Personal Author(s) : Kondo, Michio ; Miyazaki, Masaya ; Fan, Jiangin ; Watanabe, Teruo ; Kodama, Hiroaki

Report Date : 1992

Pagination or Media Count : 2

Abstract : A number of peptides and proteins such as C5a, fMLF (also known as fMLP) and Interleukin 8 exhibit biological activity as chemoattractants in inflammatory sites. In addition to the directed migration of cells, these stimulants induce a variety of coordinated biochemical and cellular responses in neutrophils and macrophages. Among these chemoattractants, fMLF is the most widely investigated. In order to elucidate the relationship between biological activity and receptor systems, the effective ligands which discriminate the receptor subtypes have been required. Dimeric analog often showed remarkable activity and high receptor selectivity for the opiate receptors.

Descriptors :   *PEPTIDES, *INFLAMMATION, POLYMORPHONUCLEAR NEUTROPHILS, RECEPTOR SITES(PHYSIOLOGY), DIMERS, LIGANDS, PROTEINS, JAPAN.

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE