Accession Number : ADP008432
Title : A Melanotropic Peptide Induces Pigmentation (Tanning) of Human Skin,
Corporate Author : ARIZONA UNIV TUCSON
Personal Author(s) : Hadley, M. E. ; Hruby, V. J. ; Levine, N. ; Dorr, R. T. ; Sharma, S. D.
Report Date : 1992
Pagination or Media Count : 2
Abstract : We have designed and biologically characterized an analog of alpha-melanocyte stimulating hormone with the following structure: Ac-Ser-Tyr-Ser-Nle-Glu-His-D-Phe-Arg-Trp-Gly-Lys-Pro-Val-NH2. The hormone analog is superpotent, prolonged acting and is resistant to inactivation by sera and proteolytic enzymes. This peptide stimulates various pigmentation in the mouse when administered topically or when injected subcutaneously. Following FDA and Human Subjects Committee approval, the peptide was delivered by subcutaneous injection to human volunteers in a phase-I clinical trial.
Descriptors : *SKIN(ANATOMY), *MELANIN, *PEPTIDES, *HORMONES, ENZYME INHIBITORS.
Subject Categories : Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE