Accession Number : ADP008435

Title :   A SAR Study of the Complete Ala and Partial Aib Scans of the Growth Hormone Releasing Factor: (Nle27hGRF(1-29)-NH2,

Corporate Author : SALK INST SWIFTWATER PA

Personal Author(s) : Cervini, L. ; Galyean, R. ; Donaldson, C. J. ; Yamamoto, G. ; Koerber, S. C.

Report Date : 1992

Pagination or Media Count : 2

Abstract : In an attempt to determine which conformational parameters are important for biological expression of GRF activity, we and others have synthesized and biologically characterized rat or human GRF(1-29)-NH2) analogs with substitution of each amino acid by its corresponding D-isomer. Interestingly, the second structural analysis of hGRF(1-29)-NH2 indicated 90% alpha-helicity in 75% MeOH at pH 6 or 20% alpha-helicity in water at pH 3 with the helical portions being centrally located.

Descriptors :   *HORMONES, *GROWTH SUBSTANCES, *PEPTIDES, ALANINES, AMINO ACIDS, ISOMERS, PH FACTOR.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE