Accession Number : ADP008436

Title :   Conformationally Constrained Glucagon Analogs: New Evidence for the Conformational Features Important to Glucagon-Receptor Interactions,

Corporate Author : ARIZONA UNIV TUCSON DEPT OF CHEMISTRY

Personal Author(s) : Lin, Ying ; Trivedi, Dev ; Siegel, Mara ; Hruby, Victor J.

Report Date : 1992

Pagination or Media Count : 2

Abstract : Structure-activity studies of glucagon suggest that the 9 to 14 region of glucagon is important for its biological activity. On the other hand, design, synthesis and conformational studies of the glucagon analog glucagon indicated that its superagonist activity was the result of enhanced alpha-helical potential in the C-terminal region. To further examine the conformational features of glucagon important for its biological activity, we have designed and synthesized four cyclic, conformationally restricted analogs.

Descriptors :   *GLUCAGON, *ADENYL CYCLASE, CHEMICAL ANALOGS, RECEPTOR SITES(PHYSIOLOGY), AMIDE HYDROLASES, PROTEINS, PANCREAS, LIVER, PANCREATIC HORMONES.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE