Accession Number : ADP008437

Title :   CCK Heptapeptide Analogs: Effect of Conformational Restrictions and Standard Modifications on Selectivity and Activity at CCK-A and CCK-B Receptors,

Corporate Author : ABBOTT LABS NORTH CHICAGO IL

Personal Author(s) : Holladay, Mark W. ; Bennett, Michael J. ; Tufano, Michael D. ; Lin, C. W. ; Witte, David G.

Report Date : 1992

Pagination or Media Count : 3

Abstract : Cholecystokinin (CCK) is a peptide hormone involved in the regulation of gall bladder contraction, pancreatic enzyme secretion, and gastric emptying. Exogenous CCK or its close analogs suppress feeding in a number of species, including man, and endogenous CCK may have a role in the normal satiety response. As part of our effort toward development of anorectic agents based on CCK, we investigated the structural and conformational requirements for activity at CCK-A and CCK-B receptor subtypes.

Descriptors :   *PEPTIDES, *HEPTANES, *PHARMACOLOGICAL ANTAGONISTS, RECEPTOR SITES(PHYSIOLOGY), CHEMICAL ANALOGS, APPETITE, GALLBLADDER, ANOREXIA, SUPPRESSORS, PANCREATIC HORMONES.

Subject Categories : Pharmacology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE