Accession Number : ADP008438

Title :   Detection and Tumor-Associated MUC-2 Epitopes by Means of Monoclonal Antibodies and Synthetic Peptides,

Corporate Author : BARCELONA UNIV (SPAIN)

Personal Author(s) : Andreu, D. ; Gambus, G. ; Jodas, G. ; de Bolos, C. ; Real, F. X.

Report Date : 1992

Pagination or Media Count : 2

Abstract : Mucins, the main component of mucus synthesized by glandular epithelial cells, are high molecular weight glycoproteins rich in Thr, Ser, Pro, Ala and Gly. 60-80% of their mass is constituted by carbohydrates O-glycosidically linked to hydroxy amino acids. Tumors derived from glandular epithelia are characterized by aberrant mucin glycosylation patterns which lead to the exposure of epitopes (peptide and carbohydrate) that are normally cryptic. Several genes encoding human mucins have been characterized and shown to have as a common feature the presence of tandem repeats of approximately 60 bp which are rich in codons encoding hydroxy amino acids.

Descriptors :   *MUCIN, *CANCER, *MONOCLONAL ANTIBODIES, COLON, CARBOHYDRATES, GLYCOPROTEINS, GLYCOSIDES, PEPTIDES, SPAIN.

Subject Categories : Biochemistry
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE