Accession Number : ADP008440

Title :   Synthesis of Lipidic Peptide Conjugates of Nucleoside Antiviral and Cytostatic Agents,

Corporate Author : LONDON UNIV (UNITED KINGDOM)

Personal Author(s) : Hussain, Rohanah ; Toth, Istvan ; Gibbons, William A.

Report Date : 1992

Pagination or Media Count : 2

Abstract : AZT is a powerful inhibitor of the reverse transcriptase (RT) enzyme. AZT does not eradicate HIV from peripheral blood mononuclear cells. The failure to clear HIV may be due to the inadequate inhibition of virus productions by macrophages. Hence, to direct larger amounts of the antiretroviral nucleosides to these cells, a major reservoir of HIV, AZT agonists or prodrugs that show increased cellular uptake are of great interest as potential anti-aids drugs. This paper presents the synthesis of fatty amino acid and oligomer conjugates.

Descriptors :   *ANTIVIRAL AGENTS, *ACQUIRED IMMUNE DEFICIENCY SYNDROME, LIPIDS, PEPTIDES, NUCLEOSIDES, FATTY ACIDS, AMINO ACIDS, HUMAN IMMUNODEFICIENCY VIRUSES, OLIGOMERS, GREAT BRITAIN.

Subject Categories : Medicine and Medical Research
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE