Accession Number : ADP008441

Title :   Synthesis and Biological Activity of Heteroalkyl Lipidic Amino Acids,

Corporate Author : LONDON UNIV (UNITED KINGDOM)

Personal Author(s) : Olmo, Esther del ; Toth, Istvan ; Fonteh, Alfred N. ; Gibbons, William A.

Report Date : 1992

Pagination or Media Count : 2

Abstract : S-Adenosylmethionine is the major methyl donor in biological processes. It is involved in lipid, steroid, protein, nucleic acid and catecholamine methylations. Phospholipid methylation in particular has been implicated in receptor mediated processes in many cell lines. It was reported that phosphatidylethanolamine (PE) molecules in the presence of fatty amino acid moieties are preferentially methylated. S-Adenosylhomocysteine is an endogenous inhibitor of biological methylation.

Descriptors :   *AMINO ACIDS, *LIPIDS, FATTY ACIDS, ENZYME INHIBITORS, METHYLATION, CYSTEINE, GREAT BRITAIN.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE