Accession Number : ADP008442

Title :   Antagonist and Agonist Activities of Synthetic Peptide Fragments of g-CSF and their Protein Conjugates,

Corporate Author : SMITHKLINE BEECHAM PHARMACEUTICALS KING OF PRUSSIA PA

Personal Author(s) : LoCastro, Stephen M. ; Silvestri, Joanne S. ; Lee, John C. ; Laydon, Jeffrey T. ; Bhatnagar, Pradip K.

Report Date : 1992

Pagination or Media Count : 2

Abstract : Granulocyte-colony stimulating factor (g-CSF) is an 18-22 kDa glycoprotein which specifically stimulates the formation of granulocyte progenitor colonies in vitro and increases neutrophil, monocyte, and eosinophil populations in a dose-dependent manner in vitro. In an epitope-mapping study undertaken in our laboratories, a Hopp and Woods hydropathic profile of g-CSF identified a series of peptide fragments as likely candidates for generating g-CSF cross-reactive antibodies.

Descriptors :   *PHARMACOLOGICAL ANTAGONISTS, *PEPTIDES, ANTIBODIES, PROTEINS(CONJUGATED), CHEMICAL ANALOGS, GLYCOPROTEINS, GRANULOCYTES.

Subject Categories : Pharmacology
      Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE