Accession Number : ADP008443
Title : Structure-Activity of TRP Modified Analogs of Ac-CCK-7,
Corporate Author : HOFFMANN-LA ROCHE INC NUTLEY NJ
Personal Author(s) : Danho, W. ; Tilley, J. ; Shiuey, S. J. ; Kulesha, I. ; Swistok, J.
Report Date : 1992
Pagination or Media Count : 2
Abstract : The analogs were synthesized using SPPS. Receptor binding of the CCK-A and CCK-B receptor subtypes was determined using solubilized membrane preparations from rat pancreatic tissue and bovine striatum, respectively. Compounds were also evaluated for their ability to suppress food intake in a meal-fed rat model.
Descriptors : *PEPTIDES, *APPETITE, RECEPTOR SITES(PHYSIOLOGY), CHEMICAL ANALOGS, PANCREATIC HORMONES, SUPPRESSORS, AMINO ACIDS.
Subject Categories : Biochemistry
Anatomy and Physiology
Distribution Statement : APPROVED FOR PUBLIC RELEASE