Accession Number : ADP008443

Title :   Structure-Activity of TRP Modified Analogs of Ac-CCK-7,

Corporate Author : HOFFMANN-LA ROCHE INC NUTLEY NJ

Personal Author(s) : Danho, W. ; Tilley, J. ; Shiuey, S. J. ; Kulesha, I. ; Swistok, J.

Report Date : 1992

Pagination or Media Count : 2

Abstract : The analogs were synthesized using SPPS. Receptor binding of the CCK-A and CCK-B receptor subtypes was determined using solubilized membrane preparations from rat pancreatic tissue and bovine striatum, respectively. Compounds were also evaluated for their ability to suppress food intake in a meal-fed rat model.

Descriptors :   *PEPTIDES, *APPETITE, RECEPTOR SITES(PHYSIOLOGY), CHEMICAL ANALOGS, PANCREATIC HORMONES, SUPPRESSORS, AMINO ACIDS.

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE