Accession Number : ADP008447

Title :   The Regulation of G Protein by Substance P-Related Peptide: Inhibition of the Effects of Mastoparan and receptor,

Corporate Author : TEXAS UNIV SOUTHWESTERN MEDICAL SCHOOL AT DALLAS

Personal Author(s) : Mukai, Hidehito ; Abe, Yoichiro ; Munekata, Eisuke ; Higashijima, Tsutomu

Report Date : 1992

Pagination or Media Count : 2

Abstract : Various amphiphilic peptides including mastoparan and substance P (SP) catalyze the activation of GTP-binding regulatory proteins (G proteins). The mechanism of the activation has been studied most intensively in the case of mastoparan, and it has been shown that mastoparan activities G proteins by a mechanism similar to that used by G protein- coupled receptors. Mastoparans are known to cause secretion from various types of cells, including histamine from mast cells, and to cause a transient increase of intracellular Ca(2+).

Descriptors :   *PROTEINS, *PEPTIDES, *PHARMACOLOGICAL ANTAGONISTS, ENZYME INHIBITORS, RECEPTOR SITES(PHYSIOLOGY), BINDERS, SECRETION, HISTAMINE.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE