Accession Number : ADP008451

Title :   SAR Studies of Cycloseptide: Effects of Cyclization and Charge at Position 6,

Corporate Author : HEBREW UNIV JERUSALEM (ISRAEL)

Personal Author(s) : Gilon, C. ; Halle, D. ; Chorev, M. ; Selinger, Z. ; Byk, G.

Report Date : 1992

Pagination or Media Count : 2

Abstract : We have recently formulated a new concept of medium and long range cyclization called backbone cyclization. In this approach, conformational constraints are conferred on a peptide by linking omega-substituted alkyl chains replacing N(alpha) and/or C(alpha) hydrogens in a peptide backbone. Backbone cyclization, which is divided into N-backbone and C-backbone Cyclizations, allow for new modes of cyclization in addition to the classical modes which are limited to cyclization through the side chains and/or the amino or carboxyl terminal groups.

Descriptors :   *PEPTIDES, *ALKYL RADICALS, *ALKYL TRANSFERASES, AMINO ACIDS, CHEMICAL ANALOGS, HYDROGEN, RECEPTOR SITES(PHYSIOLOGY), CARBOXYLIC ACIDS, ISRAEL.

Subject Categories : Biochemistry

Distribution Statement : APPROVED FOR PUBLIC RELEASE