Accession Number : ADP008541

Title :   Analogs of Growth Inhibitors of Hemopoietic and Epidermal Cells,

Corporate Author : MAGYAR TUDOMANYOS AKADEMIA BUDAPEST

Personal Author(s) : Balazs, A. ; Schoen, I. ; Szirtes, T. ; Kisfaludy, L.

Report Date : 1992

Pagination or Media Count : 2

Abstract : Growth factors and inhibitors play a pivotal role in the homeostasis of organisms. Most of these regulators of cell proliferation are polypeptides of high molecular mass and low specificity. Both their availability and clinical applicability are limited. Recently isolation, structure determination and preliminary biological studies of some cell proliferation inhibitory oligopeptides were reported. Among others they include Glp-Glu-Asp-Ser-Gly (EI) epidermal and Glp-Glu-Asp-Cys-Lys (HI) hemoregulatory inhibitors. The remarkable structural similarity and high specificity of these oligopeptides prompted us to study structure-activity relationships of HI and EI.

Descriptors :   *GROWTH(PHYSIOLOGY), *PEPTIDES, *HEMATOPOIETIC CELLS, *EPIDERMIS, INHIBITORS, ANALOGS, CELL DIVISION, HUNGARY.

Subject Categories : Biochemistry
      Anatomy and Physiology

Distribution Statement : APPROVED FOR PUBLIC RELEASE