Accession Number : ADP008543

Title :   A Series of Highly Selective Thrombin Inhibitors,

Corporate Author : LILLY (ELI) AND CO INDIANAPOLIS IN LILLY RESEARCH LABS

Personal Author(s) : Shuman, Robert T. ; Rothenberger, Robert B. ; Campbell, Charles S. ; Smith, Gerald F. ; Gifford-Moore, Donetta S.

Report Date : 1992

Pagination or Media Count : 2

Abstract : Tripeptide aldehydes such as Boc-D-Phe-Pro-Arg-H exhibit potent direct inhibition of thrombin. We have evaluated the structural and conformational role of the amino acid residue in position one of Boc-D-Phe-Pro-Arg-H.

Descriptors :   *ENZYME INHIBITORS, *THROMBIN, *AMINO ACIDS, PEPTIDES, ALDEHYDES.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE