Accession Number : ADP008544

Title :   The Rational Design of Peptide Serine Protease Inhibitors,

Corporate Author : KING'S COLL LONDON (UNITED KINGDOM)

Personal Author(s) : Wibley, K. S. ; Bansal, S. ; Barlow, D. J.

Report Date : 1992

Pagination or Media Count : 3

Abstract : Since the uncontrolled activity of serine protease enzymes is widely implicated in the pathology of disease states involving tissue destruction, there is considerable therapeutic potential for molecules designed specifically to inhibit these enzymes. In the work outlined below, the aim has been to develop a small synthetic peptide inhibitor of the serine protease, human neutrophil elastase (HNE) for the treatment of pulmonary emphysema.

Descriptors :   *ENZYME INHIBITORS, *PEPTIDE HYDROLASES, SERINE, EMPHYSEMA, GREAT BRITAIN.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE