Accession Number : ADP008551

Title :   Sequence Motifs of Peptides Eluted from MHC Molecules are Allele Specific,

Corporate Author : MAX-PLANCK-INST FUER BIOLOGIE TUEBINGEN (GERMANY F R)

Personal Author(s) : Roetzschke, Olaf ; Falk, Kirsten ; Schild, Hansjoerg ; Norda, Maria ; Rammensee, Hans-Georg

Report Date : 1992

Pagination or Media Count : 3

Abstract : A complete and fully synthetic peptide vaccine inducing humoral and cellular immune response must contain: built-in adjuvanticity for activation of B-cells and macrophages, B-cell epitopes, T-helper cell epitopes and killer cell (CTL) epitopes. Major problems in vaccine development are CTL induction in vivo and allele-specific epitope prediction. Most synthetic vaccines described to date to not meet all of these requirements, they are effective only in combination with carrier proteins and the obsolete Freund's adjuvant. we developed a novel low-molecular-weight vaccine against foot and mouth disease virus (FMDV) composed of the viral B- and T-cell epitope FMDV VPI (135-154) and the B-cell and macrophage activator tripalmitoyl-S-glyceryl-cysteinylserylserine (P3CSS). The synthesized vaccine induces a long-lasting high protection and serotype-specific virus-neutralizing antibodies in guinea-pigs, pigs and cattle after a single administration without any additional adjuvant or carrier. Here we present fundamental findings leading to an experimental data base for exact allele-specific epitope prediction.

Descriptors :   *VACCINES, *PEPTIDES, *FOOT AND MOUTH DISEASE VIRUS, *GLYCOPROTEINS, HISTOCOMPATIBILITY, GENES, GERMANY.

Subject Categories : Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE