Accession Number : ADP008553
Title : Regulation of Immune Responses by Peptides of T-Cell Receptor Variable Region,
Corporate Author : ALBERTA UNIV EDMONTON
Personal Author(s) : MacNeil, Donna ; Fraga, Ester ; Singh, Bhagirath
Report Date : 1992
Pagination or Media Count : 3
Abstract : The antigen receptor of T lymphocytes (TCR) confers antigen specificity and MHC restriction to T-cell response to antigen. The TCR is a heterodimer composed of alpha and beta or gamma and delta chains, all of which have variable NH2-terminal domains encoded by V, J or V, D, J gene regions. Nearly all T-cells bearing particular V(beta) regions on their TCR are stimulated by some antigens such as pathogenic bacterial toxins and self antigens involved in autoimmune responses. These antigens termed superantigens provide a tool in the investigation of the structure-function of molecular recognition. In order to identify putative sites on the V(beta) region which bind the superantigen, the MMTV encoded minor lymphocyte stimulating gene, we have synthesized a series of peptides of V(beta)6. The peptides of the variable region correspond to the proposed solvent-exposed beta-pleated sheet of the beta chain. We have used these peptides to inhibit the activation of T-cell hybridomas which bear V(beta)6 on their TCR and which react with the superantigen.
Descriptors : *IMMUNOLOGY, *T LYMPHOCYTES, *RECEPTOR SITES(PHYSIOLOGY), *ANTIGENS, PEPTIDES, GLYCOPROTEINS, HISTOCOMPATIBILITY, HYBRIDOMAS, CANADA.
Subject Categories : Medicine and Medical Research
Distribution Statement : APPROVED FOR PUBLIC RELEASE