Accession Number : ADP008554

Title :   Synthetic Vaccinees: The Mixotope Strategy,

Corporate Author : INSTITUT PASTEUR PARIS (FRANCE)

Personal Author(s) : Gras-Masse, Helene ; Ameisen, Jean-Claude ; Boutillon, Christophe ; Rouaix, Franck ; Bossus, Marc

Report Date : 1992

Pagination or Media Count : 3

Abstract : The hypervariability of the gp120 envelope protein principal neutralizing domain, the V3 loop, represents a major problem in the design of vaccines against HIV-1. In this region, differences as high as 50% can be found between isolates. Recombinant proteins and peptides derived from different isolates have been shown to induce mostly HIV-1 subtype-specific neutralizing antibodies. Broadly reactive, neutralizing, antibodies have been obtained using discrete mixtures of different peptides or hybrid V3-peptides. However, even though some cross-reactivities may be expected, point mutations giving rise to new variants escaping neutralization are still likely to occur. An ideal solution for a vaccine would be to recruit simultaneously the broadest part of the immune repertoire capable of recognizing not only the known isolates but also the highest possible number of escaping mutants.

Descriptors :   *VACCINES, *HUMAN IMMUNODEFICIENCY VIRUSES, PEPTIDES, PROTEIN METABOLISM, AMINO ACIDS, SYNTHESIS(CHEMISTRY), FRANCE.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE