Accession Number : ADP008555

Title :   Complete Synthetic Vaccine with Built-In Adjuvant,

Corporate Author : ROCKEFELLER UNIV NEW YORK

Personal Author(s) : Defoort, Jean-Philippe ; Nardelli, Bernardetta ; Huang, Wolin ; Shiu, Denise R. ; Tam, James P.

Report Date : 1992

Pagination or Media Count : 2

Abstract : In the conventional approach to synthetic vaccines, peptide antigens coupled to a high molecular weight protein in combination with adjuvant such as complete Freund's adjuvant are administrated as a heterogeneous mixture. Unfortunately, such a preparation is not suitable for human use due to undesirable side effects. To overcome this deficiency that hampers the progress to synthetic vaccines, we investigated a novel approach to develop a complete peptide-based synthetic vaccine with a built-in adjuvant. We covalently linked to a multiple antigen peptide (MAP) a potent B cell and macrophage activator, tripalmitoyl-S glyceryl cysteine (P3C) (2.3). Moreover, we also used this new construc liposomes which have been shown to improve the immune response. We chose as a model the peptide which is part of the principal neutralizing determinant located in the V loop of gp120 of the human immunodeficiency virus type I, III strain.

Descriptors :   *VACCINES, *SYNTHESIS(CHEMISTRY), *IMMUNOLOGY, ANTIGENS, HUMAN IMMUNODEFICIENCY VIRUSES.

Subject Categories : Biochemistry
      Pharmacology

Distribution Statement : APPROVED FOR PUBLIC RELEASE