Accession Number : ADP008707

Title :   Risk Assessment for Noncarcinogenic Chemical Effects,

Corporate Author : NATIONAL CENTER FOR TOXICOLOGICAL RESEARCH JEFFERSON AR

Personal Author(s) : Kodell, Ralph L.

Report Date : JAN 1993

Pagination or Media Count : 4

Abstract : Risk assessment for toxic chemicals that do not induce carcinogenic or mutagenic effects has traditionally been based on the fundamental assumption that there are levels of exposure for such agents below which adverse health effects will not occur, even if exposure is long term (Figure 1). Biological underpinnings for this 'thresold' concept include the fact that toxicity of many chemicals is manifest in exposed subjects only after the depletion of a known physiology reserve and that the biological repair capacity of many organisms can accommodate a certain degree of damage by reversible toxic processes. The objective of risk assessment for noncarcinogenic chemical effects has thus been to establish a 'threshold dose' below which adverse health effects are not expected to occur

Descriptors :   *RISK, *CHEMICALS, *CARCINOGENS, TOXIC HAZARDS.

Subject Categories : Operations Research
      Industrial Chemistry and Chemical Processing
      Medicine and Medical Research

Distribution Statement : APPROVED FOR PUBLIC RELEASE